Here is some buzzworthy news about America’s favorite pick-me-up: According to a review article in the prestigious New England Journal of Medicine, there is enough scientific evidence from epidemiological studies to suggest that drinking two to five cups of coffee each day is linked to a lower risk for some chronic diseases, such as type 2 diabetes and heart disease.

On the other hand, going overboard on caffeine may lead to anxiety, insomnia or psychomotor agitation (a feeling of anxious restlessness that causes a person to perform movements without meaning, such as rapid talking or pacing around a room). The report authors recommended limiting caffeine intake to 400 milligrams daily for most people (about what you would get in 4 cups of coffee) and 200 mg for women who are pregnant or lactating.