There are a number of factors that go into weight loss, and sometimes it is difficult to say where you will lose it. Without doing an assessment that is specific to you (age, health assessment, fitness level, orthopedic issues, etc.), it would not be appropriate to give you detailed information.
However, in general, you want an exercise program that includes both cardio and strength training at the intensity level appropriate for you. The bigger factor will be an evaluation of your diet. It’s not only the calories in and calories out, but the combination of foods you choose as well (proteins, healthy fats, and carbohydrates). Plus, if you are anywhere in your 40s then hormones may also play a role in difficulty with weight loss around the waist.
You may want to think about hiring a personal trainer, health coach, or registered dietician to help you with your goals. It can be done, you just need a little guidance along the way!
Good luck to you, Claudia!