I have a client who is struggling with leg cramps while he is training for his marathon. At about 15-18 miles the cramps muscle.
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I agree with Marshall and a movement/gait evaluation might solve the problem. In addition to what was mentioned before, compression socks, extra salt, foam rolling, massages, better shoes, and maybe incorporating bare foot running might add to dexterity of his feet and aid in preventing cramps.
Over training might be something to look into as well. Too much milage and speed could be the cause as well.
Good luck,
Heike Yates
www.heylifetraining.com